基質投与の最適制御および代謝ボトルネック解消のための解析的パイプラインの開発

Chem-Bio Informatics Journal

田中 重光²  花井 泰三¹  �? 祐喜¹  岡本 正宏¹  小林 元太² 

[1] 九州大学大学院生物資源環境科学府生物機能制御学研究室;佐賀大学農学部生命機能科学科応用微生物学研究室

关键词: Analytical pipeline;    解析的パイプライン;    Biofuel production;    バイオ燃料生産;    Butanol;    ブタノール;    Clostridium;    Feeding optimization;    基質投与の最適制御;    Metabolic bottleneck;    代謝ボトルネック;   

DOI  :  10.1273/cbij.11.1

学科分类：生物化学/生物物理

来源: Chem-Bio Informatics Society

【 摘 要 】

References(23)Attempts were made to design and develop an analytical pipeline for identifying ways of increasing the production of a target metabolite that combine an optimized substrate-feeding schedule with a strategy for identifying and eliminating bottlenecks in metabolic pathways. As a case study, the proposed analytical pipeline was applied to acetone-butanol-ethanol fermentation by Clostridium bacteria, a process that has attracted considerable attention as a metabolic system capable of producing butanol, a possible biofuel.

【 授权许可】

Unknown