The nuclear membrane as a lipid ‘sink’—linking cell cycle progression to lipid synthesis

Journal of Chemical Biology

Richard D. Byrne¹ 

[1] Cell Biophysics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London, WC2A 3LY UK

关键词: Nuclear membrane;    Lipid sink;    Lipid synthesis;    Nuclear morphology;    Cell cycle;   

DOI  :  10.1007/s12154-012-0082-1

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

The nuclear envelope (NE) is a double bilayer structure comprised of the inner and outer nuclear membranes, nuclear lamina and nuclear pore complexes. Not just limited to functioning as a selective barrier between the nucleus and cytoplasm, it regulates a number of cellular processes including gene expression, protein synthesis, DNA damage repair, calcium homeostasis and nuclear shape/volume [2, 6]. Highlighting the importance of nuclear integrity in cellular function, mutations in NE resident proteins lead to a number of disease states, including the ‘laminopathies’, and various cancers [4]. Striking aberrations in NE morphology are associated with several cancers, including small-cell lung cell carcinoma, papillary thyroid carcinoma, urothelial tumours, prostate cancer, invasive ductal carcinoma and high-grade breast cancer [4, 13]. Such aberrations consist of enlarged nuclei, intense staining of nucleoli with haematoxylin and eosin and prominent nuclear invaginations and protrusions [4, 13]. It should be noted that the NE is not a static structure; in eukaryotic cells, it disassembles and reassembles during mitosis. Yeasts, however, undergo a ‘closed’ mitosis, typified by nuclear elongation within which chromosomes are segregated. This process is accompanied by an increase in NE size, which also changes in shape from spheroid during interphase to an ‘hourglass’ shape during mitosis. Together, these demonstrate that understanding the pathways controlling NE shape and size is of importance.

【 授权许可】

Unknown