The Effect of Vaccination with the PAV-250 Strain Classical Swine Fever (CSF) Virus on the Airborne Transmission of CSF Virus

Journal of Veterinary Medical Science

Abel CIPRIAN¹  Susana MENDOZA¹  Pablo CORREA⁴  Carlos GONZÁLEZ³  Carlos PIJOAN² 

[1] Posgrado de la Facultad de Estudios Superiores Cuautitlan- Universidad Nacional Autonoma de México;Department of Clinical Sciences and Population, College of Veterinary Medicine, University of Minnesota;Centro Nacional de Servicios de Diagnóstico en Salud Animal, Comisión Nacional de Sanidad Agropecuaria, Secretaria de Agricultura Ganaderia y Desarrollo Rural;CENID-Microbiologia-INIFAP

关键词: airborne;    CSF virus;    PAV-250;    transmission;   

DOI  :  10.1292/jvms.63.991

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(8)The airborne transmission of Classical Swine Fever (CSF) virus to susceptible pigs, as well as the effect of vaccination with the CSF virus PAV-250 strain was investigated on this mode of transmission. Experiment I: four pigs were inoculated with the ALD CSFV strain (104.3 50% TCID) by the intramuscular route, and at the onset of fever, they were introduced into an enclosed chamber. At the end of the experiment surviving pigs were sedated, anesthetized and euthanatized. Experiment II: four pigs were previously vaccinated with the CSF virus PAV-250 strain, and at 14 days post-vaccination they were challenged with the CSF virus ALD strain. In both experiments, four susceptible pigs were exposed to infectious aerosols by placing them in a chamber connected by a duct to the adjacent pen containing the infected animals and were kept there for 86 hs. In Experiment I, pigs exposed to contaminated air died as a result of infection with CSF virus on days 14, 21 and 28 post-inhalation. These four pigs seroconverted from day 12 post-inhalation. CSF virus was isolated from these animals, and the fluorescent antibody test on tonsils was positive. In Experiment II, a vaccinated pig exposed to contaminated air did not seroconvert, nor was CSF virus isolated from lymphoid tissues. However, mild fluorescence in tonsil sections from these pigs was observed. In conclusion, CSF virus was shown to be transmitted by air at a distance of 1 m to susceptible pigs. Vaccination with the PAV-250 CSF virus strain protected the pigs from clinical disease under the same conditions.

【 授权许可】

Unknown