Changes of Magnetic Resonance Imaging on the Brain in Beagle Dogs with Aging

Journal of Veterinary Medical Science

Naoaki MATSUKI³  Tomofumi KIMOTSUKI²  Tsukasa NAGAOKA¹  Kenichiro ONO³  Satoshi TAMAHARA³  Mitsuya YASUDA² 

[1] Laboratory Department of Neurosurgery, Tokyo Medical and Dental University;Medicinal Safety Research Laboratories, Sankyo Co., Ltd.;Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

关键词: age-associated change;    brain;    canine;    hypo- and hyper-intensity;    MRI;   

DOI  :  10.1292/jvms.67.961

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(39)Cited-By(19)Age-associated changes of magnetic resonance imaging (MRI) on the brain were evaluated in 19 beagle dogs aged from 8-month- to 16-year-old. A significant correlation of the volume of lateral ventricle space was observed in the dogs with age advanced, however, no correlation was found between hippocampus size and the aging. The hypo-intensity areas on T2-weighted MRI were detected in globus pallidus and substantia nigra with a significant correlation of both intensity ratios to lateral ventricle with age advanced. These areas were coincided with the accumulation of iron in the slice of the brain with Perls' staining. In addition, hyper-intensity area, suggesting perivascular demyelination with fluid-filled space, was also observed in white matter surrounding the lateral ventricle on T2-weighted MRI. These results suggested that age-associated changes of T2-weighted MRI were developed in the dog brain, especially in globus pallidus, substantia nigra, and white matter surrounding lateral ventricle, like as those reported in the human brain.

【 授权许可】

Unknown