Thyroid-Stimulating Antibody in a Patient with Euthyroid Graves' Disease

Endocrine Journal

JURI TOKI²  MAKOTO KURIHARA²  SUSUMU KANZAKI¹  YUJI KADO²  YOSHIKI SEINO¹  TOSHIHIDE KUBO²  TADASHI MORIWAKE¹ 

[1] Department of Pediatrics, Okayama University Medical School;Department of Pediatrics, National Iwakuni Hospital

关键词: Euthyroid Graves' disease;    Thyroid-stimulating antibody;    TSH receptor antibody;   

DOI  :  10.1507/endocrj.47.197

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(18)Cited-By(4)We report an 11-year-old girl with euthyroid Graves' disease. She was referred to our clinic because of left exophthalmos without other symptoms suggestive of hyperthyroidism. Her serum concentration of free thyroxine (FT4) and free triiodothyronine (FT3) were normal, but thyroid-stimulating hormone (TSH) was below normal and impaired TSH response to TSH releasing hormone (TRH) was found. Although the sera were positivefor anti-TSH receptor antibody (TRAb) and thyroid-stimulating antibody (TSAb), both titers were not as high as usually observed in Graves' disease. Three months later, she developed hyperthyroidism and was treated with propylthiouracil. Within 2 weeks of the initiation of therapy, all symptoms except exophthalmos disappeared, and after 2 months of treatment TRAb was negative though TSAb remained positive. TSAb is therefore a good indicator to use in the diagnosis and follow-up of euthyroid Graves' disease and should be measured in patients with exophthalmos of unknown origin, even in children.

【 授权许可】

Unknown