Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms

Journal of Pharmacological Sciences

Wako Urano¹  Atsuo Taniguchi¹  Toru Kimura²  Promsuk Jutabha²  Naohiko Anzai²  Hitoshi Endou²  Hiroyuki Sakurai²  Hisashi Yamanaka¹ 

[1] Institute of Rheumatology, Tokyo Women’s Medical University, Japan;Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan

关键词: single nucleotide polymorphism;    diuretic;    urate;   

DOI  :  10.1254/jphs.10228SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(5)We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (SNPs) in the sodium-phosphate transporter NPT4 gene (SLC17A3) using the Xenopus oocyte expression system. NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [14C]para-aminohippurate, [3H]bumetanide, [3H]estrone sulfate, and [14C]urate, when each variant clone was expressed in the plasma membrane of oocytes. This study suggests the possibility that the genetic variation of NPT4 contributes to inter-individual differences in disposition of anionic drugs such as diuretics as well as certain endogenous organic anions such as urate.

【 授权许可】

Unknown