Detection of the Human Coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata, Japan

Japanese Journal of Infectious Diseases

Kazue Yahagi¹  Yoko Aoki¹  Yoko Matsuzaki²  Fumio Katsushima³  Chieko Abiko¹  Yu Suzuki¹  Yuriko Katsushima³  Tsutomu Itagaki⁴  Tatsuya Ikeda¹  Katsumi Mizuta¹  Yohei Matoba¹ 

[1] Department of Microbiology, Yamagata Prefectural Institute of Public Health;Department of Infectious Diseases, Yamagata University Faculty of Medicine;Katsushima Pediatric Clinic;Yamanobe Pediatric Clinic

关键词: coronavirus;    acute viral respiratory infections;    epidemiology;   

DOI  :  10.7883/yoken.JJID.2014.266

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(24)Cited-By(6)The available literature on human coronaviruses (HCoVs) in Japan is limited to epidemiological studies conducted over a maximum of 1 year. We conducted a 4-year study of HCoVs by analyzing 4,342 respiratory specimens obtained in Yamagata, Japan, between January 2010 and December 2013. A pan-coronavirus reverse transcription-PCR screening assay was performed, and all HCoV-positive specimens were subsequently confirmed by sequencing of the PCR products. We detected in 332 (7.6%) HCoV strains during the study period, comprising 133 (3.1%) HCoV-NL63, 83 (1.9%) HCoV-HKU1, 78 (1.8%) HCoV-OC43, and 38 (0.9%) HCoV-229E strains. HCoV detection per year ranged from 3.5% to 9.7%. HCoVs were detected mainly in winter, with January (28.5%) and February (25.3%) 2011 and December 2012 (14.6%) being the only months in which HCoV-NL63 detection per month exceeded 10.0%. HCoV-HKU1 displayed clear biennial peaks in January (18.3%) and February (10.7%) 2010 and in February (18.8%) and March (14.7%) 2012. The peak detection of HCoV-OC43 was 13.6% in November 2010, while that of HCoV-229E was 10.8% in March 2013. Our results indicated that there may be annual variations in the circulation of individual HCoV strains. Further long-term surveillance is necessary to clarify HCoV prevalence and circulation patterns in Japan.

【 授权许可】

Unknown