Intercellular synchronization of diffusively coupled Ca2+ oscillators

Journal of Chemical Biology

Md. Jahoor Alam¹  Gurumayum Reenaroy Devi¹  Latika Bhayana¹  R. K. Brojen Singh¹  Heisnam Dinachandra Singh¹  B. Indrajit Sharma² 

[1] Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025 India;Department of Physics, Assam University, Silchar, 788 011 Assam India

关键词: Cell signaling;    Synchronization;    Diffusive coupling;    Network topology;    Chemical coupling;   

DOI  :  10.1007/s12154-011-0066-6

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

We examine the synchrony in the dynamics of localized [Ca2 + ]i oscillations among a group of cells exhibiting such complex Ca2 +  oscillations, connected in the form of long chain, via diffusing coupling where cytosolic Ca2 +  and inositol 1,4,5-triphosphate are coupling molecules. Based on our numerical results, we could able to identify three regimes, namely desynchronized, transition and synchronized regimes in the (T − ke) (time period-coupling constant) and (A − ke) (amplitude-coupling constant) spaces which are supported by phase plots (Δϕ verses time) and recurrence plots, respectively. We further show the increase of synchronization among the cells as the number of coupling molecules increases in the (T − ke) and (A − ke) spaces.

【 授权许可】

Unknown