Pharmacokinetics of marbofloxacin after intravenous and intramuscularadministration in Hanwoo, Korean native cattle

Journal of Veterinary Medical Science

Seung-Jin LEE¹  Sileshi BELEW¹  Yong-Soo PARK³  Jin-Yoon KIM¹  Joo-Won SUH²  Jong-Choon KIM⁴  Ji-Yong PARK¹  Md.Akil HOSSAIN¹  Seung-Chun PARK¹ 

[1] Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Daegu 702�?701, Republic of Korea;Center for Nutraceutical and Pharmaceutical Materials, Division of Bioscience and Bioinformatics, Science campus, Myongji University, Yongin 449�?728, Gyeonggi, Republic of Korea;Department of Equine Industry, Korea National College of Agriculture and Fisheries, Hwaseong 445�?760, Republic of Korea;College of Veterinary Medicine, Chonnam National University, Gwangju 500�?757, Republic of Korea

关键词: Hanwoo;    Korean cattle;    marbofloxacin;    pharmacokinetics;   

DOI  :  10.1292/jvms.14-0221

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Pharmacokinetic (PK) parameters of marbofloxacin (MRFX) in Korean cattle, Hanwoo, weredetermined following its intravenous (i.v.) or intramuscular (i.m.) administration at adose of 2 mg/kg. Area under the curve (AUC0�?24 hr), half-life (t1/2)and total body clearance (CLB) of i.v. MRFX were 6.87hr∙µg/ml, 2.44 hr and 0.29 l/kg∙hr,respectively, and the corresponding values for i.m. administration of MRFX were 5.07hr∙µg/ml, 2.44 hr and 0.39 l/kg∙hr.The suggested optimal doses of MRFX in Hanwoo cattle, calculated by integration of PK dataobtained in the present study and previously reported minimum inhibitory concentration(MIC) for MRFX against susceptible (MIC �?1 µg/ml) andintermediate (MIC �?2 µg/ml) pathogenic bacteria, were2.1 and 4.2 mg/kg/day by i.v. route and 3.9 and 7.8 mg/kg/day by i.m. route.

【 授权许可】

Unknown