Suppressive Effect of Fetal Testes on Development of Fetal Ovaries Transplanted into Adult Males in the Rat

Journal of Veterinary Medical Science

Masako YAMAMOTO¹  Yasuhiro NAMBA¹  Masahiko KUSANAGI¹  Kazuyoshi ARISHIMA¹  Yasunobu EGUCHI¹ 

关键词: differentiation;    fetus;    ovary;    rat;    testis;   

DOI  :  10.1292/jvms.56.1113

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)The age-related testicular effect on the ovarian primordia was studied by combined transplantation of fetal testes and ovaries in adult male hosts. First, ovarian primordia of 14-day fetal rats were transplanted into a renal subcapsular position of castrated or intact adult male rats. In both the castrated and the intact hosts, most of the ovarian transplants developed normally with only 3 of them having in part seminiferous tubule-like structures in addition to normal ovarian structure. Second, a 14-day ovary was combined with a fetal testis the age of which varied from 13- to 18-day, and the combination was transplanted. In the combination of a 14-day ovary and a 13-day testis, the results varied in such a way that the ovary or the testis alone developed or otherwise, both gonads developed well. In union with 15- to 18-day testes, the ovaries did not develop, although the testes developed well. These results suggest that the 14-day ovarian primordia have a slight reactiveness to androgens of host rats and that the 13-day fetal testes begin to inhibit the development of the 14-day ovaries co-transplanted with them.

【 授权许可】

Unknown