Age-Related Changes in Rat Hippocampal Theta Rhythms: A Difference between Type 1 and Type 2 Theta

Journal of Veterinary Medical Science

Keiichiro Toyosawa¹  Yasuyuki Abe² 

[1] Laboratory of Applied Physiology, Faculty of Agriculture, Kobe University, Rokkodai, Nada-ku, Kobe 657-0013, Japan;Department of Intelligent Science, Graduate School of Science and Technology, Faculty of Agriculture, Kobe University, Rokkodai, Nada-ku, Kobe 657-0013, Japan

关键词: aging;    hippocampus;    rat;    theta rhythm;   

DOI  :  10.1292/jvms.61.543

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(10)The age-related changes in two types of theta rhythms recorded from the hippocampus in young (4 months-old), mature (12-13 months-old) and aged (22-25 months-old) rats were investigated. The type 1 theta rhythm was measured from hippocampal EEG recorded from walking rats and the type 2 theta was measured from the EEG induced by reticular pontin oralis nucleus (PON) stimulation in urethane anesthetized rats. The peak frequency and the peak power were detected from power spectra calculated on each theta sample by fast Fourier transformation (FFT). No age-related alteration was observed on the peak frequency of type 1 theta rhythm. However, on type 2 theta rhythm, the peak frequency was decreased in the aged rats compared with the young and the mature rats. The type 2 theta rhythm is cholinergic, and therefore this result suggests that age-related deterioration can be clearly observed in the cholinergic system including the hippocampus in rats.

【 授权许可】

Unknown