The Antiproliferative Effect of Bovine Lactoferrin on Canine Mammary Gland Tumor Cells

Journal of Veterinary Medical Science

Jun YASUDA²  Mikinori KUWABARA¹  Nobuyuki TOMIZAWA²  Reeko SATO²  Saori KOBAYASHI²  Yuichi YAMADA³  Yutaka MOMOTA²  Careen HANKANGA²  Osamu INANAMI¹ 

[1] Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University;Department of Small Animal Internal Medicine, Faculty of Agriculture, Iwate University;Department of Veterinary Clinical Science, The United Graduate School of Veterinary Science, Gifu University

关键词: bovine lactoferrin;    canine mammary gland tumor cell;    G1 arrest;   

DOI  :  10.1292/jvms.70.443

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)Cited-By(11)Lactoferrin has several biological activities, including antitumor activities in some human and animal tumor cells. Clinical trials have been carried out in human medicine based on these effects. However, the antitumor effects of lactoferrin in veterinary medicine remain unknown. In this in vitro study, we demonstrated that co-incubation of canine mammary gland tumor cells (CIPp and CHMp) and bovine lactoferrin induced growth arrest of tumor cells. This growth arrest was associated with induction of G1 arrest. Furthermore, this effect was stronger in tumor cells than in normal cells. These findings demonstrate that bovine lactoferrin has anti-tumor activity in canine mammary tumors and has the potential for use in tumor-bearing dogs.

【 授权许可】

Unknown