CC Chemokine Receptor 4-Positive CD4+ Lymphocytes in Peripheral Blood Increases during Maturation in Healthy Beagles

Journal of Veterinary Medical Science

Kenichi MASUDA²  Nobutaka YASUDA²  Sadatoshi MAEDA¹ 

[1] Department of Veterinary Internal Medicine, Faculty of Applied Biological Sciences, Gifu University;Animal Allergy Clinical Laboratories Inc.

关键词: canine;    CCR4;    lymphocyte;   

DOI  :  10.1292/jvms.70.989

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(2)In this study, percentages of CCR4+ cells in peripheral CD4+ T-lymphocytes were examined with flow cytometry in 46 healthy beagles between 3 months and 7 years of age. The percentage of CCR4+ cells varied from 9.9% to 33.5%. The mean percentage was significantly lower in the group with ages of less than 1 year than those with ages equal to or more than 1 year (p<0.05), suggesting that maturation might increase the CCR4+ T-lymphocyte subset. No influence of aging on the percentages was detected among the groups with ages equal to or more than 1 year. The findings are useful for establishing a reference value for the percentage of peripheral CCR4+CD4+ lymphocytes in dogs.

【 授权许可】

Unknown