Serum Pattern of Circulating Adipokines throughout the Physiological Menstrual Cycle

Endocrine Journal

Georgia KABOUROMITI¹  Androniki TROUSSA³  Mara SIMOPOULOU³  Athanasios MILOUSIS³  Byron ASIMAKOPOULOS³  Gregory TRIPSIANIS³  Nikos NIKOLETTOS²  Theodora GIOKA¹  George GIANISSLIS³  Simoni KATERGARI³ 

[1] Department of Biopathology, General University Hospital of Alexandroupolis;IVF Unit, General University Hospital of Alexandroupolis, Democritus University of Thrace;Laboratory of Physiology, School of Medicine, Democritus University of Thrace

关键词: resistin;    adiponectin;    leptin;    menstrual cycle;    reproduction;   

DOI  :  10.1507/endocrj.K08E-222

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(33)Cited-By(16)This study investigated the serum levels of resistin, adiponectin and leptin during the physiological menstrual cycle. Sixteen women (age: 19-30 years; body mass index: 19.46-24.9) with regular menstrual cycles participated. Fasting blood samples were collected on alternate days throughout a full menstrual cycle. Mean resistin concentrations were slightly higher during the luteal phase (5.30±0.23 ng/ml) compared to the follicular (4.68±0.07 ng/ml) and midcycle (4.86±0.09 ng/ml) phases (p=0.032). Mean leptin concentrations during the follicular phase (18.14±0.28 ng/ml) were significantly lower compared to the midcycle (21.79±0.29 ng/ml, p=0.006) and luteal phases (23.75±0.64 ng/ml, p<0.001). The variation of adiponectin concentrations throughout the menstrual cycle was not significant. According to the results, circulating resistin, likewise leptin concentrations vary significantly during the physiological menstrual cycle presenting with higher values during the luteal phase. This pattern, although its physiological importance is not clear, suggests that resistin, likewise to leptin, may have a role in the regulation of cyclic female reproductive functions. The stable adiponectin concentrations throughout the menstrual cycle indicate that this adipokine probably does not play a considerable role in female reproductive functions.

【 授权许可】

Unknown