Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction

Nutrients

ConcepciónMaría Aguilera-García¹  JuanLuis Pérez-Navero²  Mercedes Gil-Campos²  Katherine Flores-Rojas²  MaríaJosede la Torre-Aguilar²  MaríaCarmen Muñoz-Villanueva³  MaríaDolores Ordóñez-Díaz⁴ 

[1] Biomedical Research Center—Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28029 Madrid, Spain;Unit of Metabolism and Paediatric Research, Maimonides Institute for Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, 14005 Córdoba, Spain;Unit of Methodology in Investigation, Maimonides Institute for Biomedical Research (IMIBIC), 14005 Córdoba, Spain;Unit of Neonatology, Department of Paediatrics, Maimonides Institute for Biomedical Research (IMIBIC), Reina Sofia Hospital, University of Córdoba, 14005 Córdoba, Spain;

关键词: metabolic syndrome;    programming;    adiponectin;    leptin;    resistin;    prematurity;   

DOI  :  10.3390/nu12041201

来源: DOAJ

【 摘 要 】

Adipose tissue programming could be developed in very preterm infants with extrauterine growth restriction (EUGR), with an adverse impact on long-term metabolic status, as was studied in intrauterine growth restriction patterns. The aim of this cohort study was to evaluate the difference in levels of plasma adipokines in children with a history of EUGR. A total of 211 school age prepubertal children were examined: 38 with a history of prematurity and EUGR (EUGR), 50 with a history of prematurity with adequate growth (PREM), and 123 healthy children born at term. Anthropometric parameters, blood pressure, metabolic markers and adipokines (adiponectin, resistin, leptin) were measured. Children with a history of EUGR showed lower values of adiponectin (μg/mL) compared with the other two groups: (EUGR: 10.6 vs. PREM: 17.7, p < 0.001; vs. CONTROL: 25.7, p = 0.004) and higher levels of resistin (ng/mL) (EUGR: 19.2 vs. PREM: 16.3, p =0.007; vs. CONTROL: 7.1, p < 0.001. The PREM group showed the highest values of leptin (ng/mL), compared with the others: PREM: 4.9 vs. EUGR: 2.1, p = 0.048; vs. CONTROL: 3.2, p = 0.029). In conclusion, EUGR in premature children could lead to a distinctive adipokines profile, likely associated with an early programming of the adipose tissue, and likely to increase the risk of adverse health outcomes later in life.

【 授权许可】

Unknown