Genetics of obesity

Public Health Nutrition

Amelia Martí¹  María Jesús Moreno-Moreno¹  Alfredo Martínez-Hernández¹  Luís Enríquez¹ 

关键词: Obesity;    Genetics;    Energy expenditure;   

DOI  :  10.1017/S1368980007000626

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

ObjectiveThe aim was to review and update advances in genetics of obesity.DesignAnalysis and interpretation of recent investigations about regulating the energy balance as well as about gene-nutrient interactions and current nutrigenomic research methods.Background and main statementsObesity results from a long-term positive energy balance. However, its rising prevalence in developed and developing societies must reflect lifestyle changes, since genetic susceptibility remains stable over many generations. Like most complex diseases, obesity derives from a failure of adequate homoeostasis within the physiological system controlling body weight. The identification of genes that are involved in syndromic, monogenic and polygenic obesity has seriously improved our knowledge of body weight regulation. This disorder may arise from a deregulation at the genetic level (e.g. gene transcription or altered protein function) or environmental exposure (e.g. diet, physical activity, etc.).ConclusionsIn practice, obesity involves the interaction between genetic and environmental factors.

【 授权许可】

Unknown