Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children

Endocrine Journal

Myoungsook Lee⁶  Geum Joo Cho¹  Kyungdo Han⁴  Taik Gun Hwang³  Hye Young Lee¹  Jung Hwan Kim⁵  Seung Hwan Lee¹  Byung-Joon Ko¹  Seon Mee Kim¹  Hye Soon Park² 

[1] Department of Family Medicine, College of Medicine, Korea University, Seoul 136-713, South Korea;Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea;Guro-Gu Public Health Centre, Seoul 152-055, South Korea;Department of Biostatistics, College of Medicine, Catholic University, Seoul 137-701, South Korea;Department of Family Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul 139-872, South Korea;Department of Food and Nutrition, Sungshin Women’s University, Seoul 142-732, South Korea

关键词: Vaspin;    Leptin;    Children;    Obesity;   

DOI  :  10.1507/endocrj.EJ12-0384

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(5)Adipokines are associated with obesity.However, the relationships between adipokines, specifically vaspin, obesity, and obesity-related variables remain controversial, and only a few studies have been conducted which examines them in children.We investigated the relationships between obesity in prepubertal Korean children and three types of adipokines: vaspin, leptin, and visfatin.In this cross-sectional study, 168 nine-year-old boys and 176 nine-year-old girls participated in a school-based health examination program.Children were classified as overweight using the Korean Pediatric Society 2007 guidelines.Overweight boys and girls had higher leptin and vaspin levels than both boys and girls of normal weight, whereas only overweight boys had higher visfatin levels than normal weight boys.Leptin, visfatin and vaspin concentrations were correlated with obesity-related variables.A multiple logistic regression analysis showed that systolic blood pressure (SBP), total cholesterol (TC), alanine aminotransferase (ALT), homeostasis model assessment of insulin resistance (HOMA-IR), leptin, and vaspin were associated with an increased risk of being overweight, whereas high-density lipoprotein (HDL) cholesterol was associated with a decreased risk of being overweight.Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children.

【 授权许可】

Unknown