Diseases of Aquatic Organisms | |
Toxicity and pathological effects of orally and intraperitoneally administered ivermectin onsea bass Dicentrarchus labrax | |
V. Ragias1  N.Liberis1  M. Roth1  F. Athanassopoulou1  S. Hatzinikolaou1  | |
关键词: Ivermectin; Sea bass; Dicentrarchus labrax; Toxicity; Histopathology; | |
DOI : 10.3354/dao052069 | |
学科分类:生物科学(综合) | |
来源: Inter-Research | |
【 摘 要 】
ABSTRACT: The toxicity and histopathology of ivermectin was studied in 3 and 35 g sea bass Dicentrarchus labrax L. following in-feed, oral intubation and injection administration at dose rates ranging from 0.5 to 3.5 mg kg-1. EstimatedLD50 values for 3 g fish were 0.335 and 0.106 mg kg-1 following oral intubation and injection administration respectively, for fish reared at 11°C; and 0.839 and 1.023 mg kg-1 following oral intubation and injectionadministration, respectively for fish reared at 20°C.For 35 g fish reared at 11°C, the estimated LD50 was 0.523 and 0.361 mg kg-1 following oral intubation and injection administration respectively. No signs of toxicity wereobserved when the compound was administered via the feed at 0.5 and 0.7 mg kg-1. However, toxicity (> 10%) was observed at dose rates of 0.2 mg kg-1 and higher when the compound was administered via oral intubation and at 0.5 mgkg-1 when administered via injection. The compound was significantly more toxic to fish reared at 11°C than at 20°C. Further, ivermectin was more toxic to 3 g than to 35 g sea bass when administered via injection. Histopathological examinationof the major organs revealed pathology was largely restricted to gills and intestinal tissue. In 3 g sea bass, lesions were also found in the kidneys.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201911300124654ZK.pdf | 368KB | download |