The Natural PPAR Agonist Linoleic Acid Stimulated Insulin Release in the RatPancreas

Journal of Veterinary Medical Science

Min-Chuan LAI²  Tzu-Hua TENG¹  Chi YANG² 

[1]Food and Drug Administration, Department of Health, Executive Yuan No.161�?2, Kunyang St., Nangang Dist., Taipei City 115 Taiwan, R.O.C.

[2]Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, No.250, Kuo Kuang Road, Taichung City, Taiwan 402, R.O.C.

关键词: arachidonic acid;    insulin;    insulin secretion;    linoleic acid;    pancreas;   

DOI  :  10.1292/jvms.13-0189

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Free fatty acids play an important role in regulating animal insulin secretion response.Acute elevated free fatty acids increased animal insulin secretion and glucose-stimulatedinsulin secretion. In the present study, we perfused the rat pancreas to explore theeffect of unsaturated fatty acids on insulin secretion. The results showed that linoleicacid, γ-linolenic acid and arachidonic acid significantly stimulated insulin secretion.Glucose (10 mM) alone induced a biphasic insulin secretion response. The peak effluentinsulin concentrations increased by 444% and 800% compared with the baseline in the firstand second insulin secretion phases, respectively. Based on comparison of the percentageincreases, arachidonic acid, γ-linolenic acid or linoleic acid increased glucose-inducedinsulin release by 555% and 934%, 522% and 995% and 463% and 1,105% in the first andsecond insulin secretion phases, respectively. However, the percentage increases ofinsulin secretion decreased significantly to 402% and 564% in the first and second phasesin the rats fed a high-fat diet for 13 weeks. Linoleic acid alone stimulated a 391%increase in the peak insulin concentration compared with the baseline in the rats fed anormal diet. The peak insulin concentration decreased significantly to183% in the rats feda long-term high-fat diet. All the results suggested that unsaturated fatty acidsstimulated insulin secretion and additively increased glucose-induced insulin secretion inthe perfused rat pancreas. However, the rats fed a high-fat diet had a decreased linoleicacid-induced insulin secretion response.

【 授权许可】

Unknown