Replacement of Internal Protein Genes, with the Exception of the Matrix, in Equine 1 Viruses by Equine 2 Influenza Virus Genes during Evolution in Nature

Journal of Veterinary Medical Science

Jiro Yasuda⁴  Hiroshi Kida¹  Koichi Otsuki²  Maki Ohira²  Yoshihiro Kawaoka³  Hiroki Takakuwa¹  Toshihiro Ito² 

[1] Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan;Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori 680-0945, Japan;Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive West, Madison, Wisconsin 53706, U.S.A.;Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-0071, Japan

关键词: equine influenza;    hemagglutinin;    matrix protein;   

DOI  :  10.1292/jvms.61.987

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(5)To establish the evolutionary association between the equine 1 H7 HA and M genes, phylogenetic analyses of the six internal gene segments of equine 1 influenza viruses (H7N7 subtype) were performed using partial nucleotide sequences. The results demonstrated that five internal genes (PB1, PB2, PA, NP and NS) of equine 1 viruses isolated after 1964 were replaced by those of equine 2 H3N8 viruses. However, the M gene was maintained during the evolution of these equine 1 viruses. These findings suggest a functional association between equine H7 HA and M gene products, most likely M2 protein.

【 授权许可】

Unknown