Effects of Chitin and Chitosan on Collagen Synthesis in Wound Healing

Journal of Veterinary Medical Science

Kazuo KOJIMA³  Saburo MINAMI³  Yoshiharu OKAMOTO³  Kazuya KOJIMA²  Yoshihiro SHIGEMASA¹  Katsuyuki MIYATAKE³  Hiroshi FUJISE² 

[1] Department of Materials Science, Faculty of Engineering, Tottori University;Department of Veterinary Pathology II, Azabu University, School of Veterinary Medicine;Department of Veterinary Surgery, Faculty of Agriculture, Tottori University

关键词: chitin;    chitosan;    prolyl hydroxylase;   

DOI  :  10.1292/jvms.66.1595

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(39)Collagen synthesis was evaluated by measuring prolyl hydroxylase (PHL) activity induced within rat granulation tissue by a polyester non-woven fabric (NWF, 1 × 1 cm, 0.6 mm in thickness) impregnated with a chitin or chitosan suspension ranging in concentration from 0.1 to 10 mg/ml. In addition, PHL activity induced in rat granulation tissue by a NWF impregnated with a phosphate buffer solution was examined as a control. The PHL activity in each group remained low until 4 days post-implantation (Day 4). However, in the 10 mg chitin group, the PHL activity increased rapidly without scatter of the data at Day 7 and remained at a plateau until Day 14. In other groups, PHL activity increased linearly until Day 14. The data varied widely at Day 7. Compared to chitosan, chitin at the higher concentration was found to induce stable collagen synthesis in the early wound healing process.

【 授权许可】

Unknown