Urinary Iodine Kinetics after Oral Loading of Potassium Iodine

Endocrine Journal

Shunichi YAMASHITA¹  Igor TARASIUK⁵  Aiko HAMADA¹  Ninpei YAMAGUCHI³  Mariko MINE¹  Kiyoshi AOYAGI³  Noboru TAKAMURA³  Nahoe MATSUSHITA²  Toshinori OHASHI⁴ 

[1] Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences;Nutrition Management Room, Nagasaki University Hospital;Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences;Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd.;Gomel State Medical Institute, Gomel, The Republic of Belarus

关键词: Potassium iodide;    Iodine-rich area;    Urinary iodine;    Thyroid;    Radiation emergency;   

DOI  :  10.1507/endocrj.50.589

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(13)Cited-By(12)We studied the kinetics of iodine in various forms, in order to establish appropriate guidelines of iodine prophylaxis for thyroid blockade at nuclear emergency in "iodine rich areas", such as Japan. First, the effect of equivalent dose of potassium iodide (KI) (solution vs. tablet) was evaluated with excretions of urinary iodine (UI) at Nagasaki, Japan, and it was revealed that there was no difference of iodine kinetics between solution and tablet. We also performed the same study at Gomel, Belarus, which was known to be an iodine deficient area, and obtained the same results. Second, the kinetics of iodine included in "iodine rich" food was also evaluated with excretions of UI. Interestingly, the ratio of UI excretion with iodine rich food was significantly lower than that with KI tablets until 6 h after the intake (ANOVA, p = 0.02). These results proved that 1) KI solution as well as its tablet is useful for prophylaxis and 2) prophylaxis by iodine rich food is not effective for rapid blockade of thyroid gland at nuclear emergency. Finally, we emphasized that the approach from social medicine is definitely important to establish an effective iodine prophylaxis.

【 授权许可】

Unknown