Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation

Journal of Pharmacological Sciences

Masanori Yoshizumi¹  Nermin Ali¹  Yoshiko Fujita¹  Toshiaki Tamaki¹  Yuki Izawa¹  Keisuke Ishizawa¹  Koichiro Tsuchiya²  Aiko Yamauchi³  Moe Kyaw¹  Yasuhisa Kanematsu¹ 

[1] Department of Pharmacology, The University of Tokushima Graduate School of Medicine;Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokushima;Department of Pharmaceutical Information Science, Graduate School of Pharmaceutical Sciences, The University of Tokushima

关键词: N-acetylcysteine;    glutathione;    vascular smooth muscle cell;   

DOI  :  10.1254/jphs.SC0040061

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(16)Cited-By(11)We examined the effects of the stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on cellular glutathione (GSH) concentration and whether NAC-regulated cellular GSH levels are directly associated with angiotensin II (Ang II)-induced intracellular signaling events in vascular smooth muscle cells (VSMC). Both L-NAC and D-NAC similarly increased intracellular GSH concentration. We found that L-NAC and D-NAC both inhibited Ang II-induced c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and [3H]-thymidine incorporation in VSMC. Our present study indicates the comparable effects of NAC stereoisomers in regulating intracellular GSH and the redox-dependent intracellular signaling mechanisms in VSMC.

【 授权许可】

Unknown