Differences in Lipid Peroxidation and Cu,Zn-Superoxide Dismutase in the Hippocampal CA1 Region Between Adult and Aged Dogs

Journal of Veterinary Medical Science

Je Kyung SEONG³  Dae Won KIM²  Hua LI¹  In Koo HWANG³  In Se LEE³  Sun Shin YI³  Moo-Ho WON¹  Yeo Sung YOON³  Ki-Yeon YOO¹  Jung Hoon CHOI³ 

[1] Department of Anatomy and Neurobiology, College of Medicine, Hallym University;Central Research Institute, Natural F&P Co., Ltd.;Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University

关键词: adult and aged dog;    Cu;    Zn-superoxide dismutase;    hippocampal CA1 region;    lipid peroxidation;   

DOI  :  10.1292/jvms.70.273

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(25)Cited-By(11)Reactive oxygen species have been long associated with oxidative stress relevant to many pathological damages. In brain, 4-hydroxy-2E-nonenal (HNE), a major cytotoxic end product of lipid peroxidation, is produced. In contrast, superoxide dismutase (SOD), one of the major antioxidant enzymes, protects neurons from oxidative stress. The aim of this study is to observe differences in the distribution of HNE and Cu,Zn-superoxide dismutase (SOD1) in the hippocampal CA1 region of adult (2-3 years of age) and aged (10-12 years of age) dogs. The HNE immunoreactivity and protein level in the CA1 region were significantly high in the aged dogs compared to those in the adult dogs. SOD1 immunoreactivity and its protein level were also higher in the aged dogs than those in the adult dogs. However, there were not significant differences in NeuN (a neuron-specific soluble nuclear antigen) immunoreactivity in CA1 neurons between the adult and aged dogs. These differences may be associated with oxidative stress in aged dogs compared to that in adult dogs.

【 授权许可】

Unknown