Journal of Veterinary Medical Science | |
Differences in Lipid Peroxidation and Cu,Zn-Superoxide Dismutase in the Hippocampal CA1 Region Between Adult and Aged Dogs | |
Je Kyung SEONG3  Dae Won KIM2  Hua LI1  In Koo HWANG3  In Se LEE3  Sun Shin YI3  Moo-Ho WON1  Yeo Sung YOON3  Ki-Yeon YOO1  Jung Hoon CHOI3  | |
[1] Department of Anatomy and Neurobiology, College of Medicine, Hallym University;Central Research Institute, Natural F&P Co., Ltd.;Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University | |
关键词: adult and aged dog; Cu; Zn-superoxide dismutase; hippocampal CA1 region; lipid peroxidation; | |
DOI : 10.1292/jvms.70.273 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(25)Cited-By(11)Reactive oxygen species have been long associated with oxidative stress relevant to many pathological damages. In brain, 4-hydroxy-2E-nonenal (HNE), a major cytotoxic end product of lipid peroxidation, is produced. In contrast, superoxide dismutase (SOD), one of the major antioxidant enzymes, protects neurons from oxidative stress. The aim of this study is to observe differences in the distribution of HNE and Cu,Zn-superoxide dismutase (SOD1) in the hippocampal CA1 region of adult (2-3 years of age) and aged (10-12 years of age) dogs. The HNE immunoreactivity and protein level in the CA1 region were significantly high in the aged dogs compared to those in the adult dogs. SOD1 immunoreactivity and its protein level were also higher in the aged dogs than those in the adult dogs. However, there were not significant differences in NeuN (a neuron-specific soluble nuclear antigen) immunoreactivity in CA1 neurons between the adult and aged dogs. These differences may be associated with oxidative stress in aged dogs compared to that in adult dogs.
【 授权许可】
Unknown
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