Association between age at menarche and diabetes in Korean post-menopausal women: results from the Korea National Health and Nutrition Examination Survey (2007-2009)

Endocrine Journal

Hye Kyung Chung²  Kyong won Lee¹  Yoonsu Cho³  Min-Jeong Shin³  Eunjung Hwang³ 

[1] Department of Public Health Sciences, Graduate School, Korea University, Seoul 136-713, Republic of Korea;Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul 120-749, Republic of Korea;Department of Food and Nutrition, Korea University, Seoul 136-713, Republic of Korea

关键词: Menarche;    Diabetes;    Body mass index;    Waist circumference;    Fasting blood glucose;   

DOI  :  10.1507/endocrj.EJ15-0192

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(40)Cited-By(1)Early menarche is known to be associated with diabetes, however this association remains controversial.Our study aimed to investigate the possible association between age at menarche and diabetes prevalence in post-menopausal Korean women.This study included 3,254 post-menopausal Korean women aged 50-85 years from the Korea National Health and Nutrition Examination Survey IV (KNHANES 2007-2009).Logistic regression analyses were used to estimate odds ratios (ORs) for diabetes prevalence.Levels of biochemical markers were compared according to groups by age at menarche.Women in the earlier menarche age group (10-12 years) showed higher levels of fasting blood glucose (FBG) and scores of homeostatic model assessment in the insulin resistance (HOMA-IR) index than other groups (p <0.05).After adjusting for potential confounding factors, early age at menarche was significantly associated with a higher prevalence of diabetes (OR 1.86, 95% confidence intervals [CI] 1.07-3.23).The observed association remained significant despite additional adjustment for body mass index and waist circumference (OR 1.82, 95% CI 1.03-3.23) and despite further adjustments for FBG levels and HOMA-IR index (OR 2.25, 95% CI 1.11-4.55).Our findings strengthen the hypothesis that younger age at menarche is associated with increased diabetes prevalence in the Korean population.

【 授权许可】

Unknown