Sargassum hemiphyllum Inhibits Atopic Allergic Reaction via the Regulation of Inflammatory Mediators

Journal of Pharmacological Sciences

Seong-Gum Ko²  Byoung-Wook Choi³  Hyun-Ah Jung⁴  Hee-Jung Lee⁴  Seung-Heon Hong²  Ho-Jeong Na⁵  Phil-Dong Moon²  Bong-Ho Lee³  Hyung-Min Kim⁵  Jay-Min Oh¹  Youngwan Seo⁴ 

[1] Department of Anatomy, School of Medicine, Wonkwang University;College of Oriental Pharmacy, Wonkwang University;Department of Applied Chemistry, Hanbat National University;Division of Ocean Science, Korea Maritime University;College of Oriental Medicine, Kyung Hee University

关键词: Sargassum hemiphyllum;    histamine;    cytokine;    mast cell;    atopic dermatitis;   

DOI  :  10.1254/jphs.FP0040326

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(59)Cited-By(12)Sargassum hemiphyllum (SH) has long been used in Korean folk medicine for the therapeutic treatment of various allergic diseases. The effects of SH in previous experimental models, however, have been inconclusive. We studied the effects of methanol extract of SH on mast cells. Our experiments showed that SH significantly inhibited compound 48/80-induced histamine and β-hexosaminidase release from rat peritoneal mast cells. SH inhibited interleukin (IL)-8 and tumor necrosis factor (TNF)-α release induced by phorbol 12-myristate 13-acetate and A23187 from HMC-1, and it also showed an inhibitory effect on the anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction. In addition, SH inhibited the increase of TNF-α-induced NF-κB protein levels, transcription factor of TNF-α from 293T cells. A period of 48 h exposure to SH had little effect on HMC-1 cell viability. Our results suggest that SH has an inhibitory effect on the atopic allergic reaction and thus this may be useful in the treatment of allergic inflammatory diseases, such as atopic dermatitis.

【 授权许可】

Unknown