Acute effects of intravenous dronedarone on electrocardiograms, hemodynamics and cardiac functions in anesthetized dogs

Journal of Veterinary Medical Science

Anusak KIJTAWORNRAT³  Chollada BURANAKARL³  Suwanakiet SAWANGKOON³  Nakkawee SAENGKLUB¹  Vudhiporn LIMPRASUTR³  Robert L. HAMLIN² 

[1] Graduate Student in the Program of Animal Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand;QTest Labs, LLC. 6456 Fiesta Dr., Columbus, OH 43235, U.S.A.;Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand

关键词: canine;    dronedarone;    hemodynamics;    inotropy;    lusitropy;   

DOI  :  10.1292/jvms.15-0413

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(42)Cited-By(1)Dronedarone is a class III antiarrhythmic that has been used for management of atrial fibrillation in humans, but limited information was found in dogs. The objective of this study was to determine the acute effects of escalating concentrations of dronedarone on electrocardiograms (ECG), hemodynamics and cardiac mechanics in healthy dogs. A total of 7 beagle dogs were anesthetized with isoflurane and instrumented to obtain lead II ECG, pressures at ascending aorta, right atrium, pulmonary artery and left ventricle, and left ventricular pressure-volume relationship. Five dogs were given vehicle and followed by escalating doses of dronedarone (0.5, 1.0 and 2.5 mg/kg, 15 min for each dose), and two dogs were used as a vehicle-treated control. All parameters were measured at 15 min after the end of each dose. The results showed that all parameters in vehicle-treated dogs were unaltered. Dronedarone at 2.5 mg/kg significantly lengthened PQ interval (P<0.01), reduced cardiac output (P<0.01) and increased systemic vascular resistance (P<0.01). Dronedarone produced negative inotropy assessed by significantly lowered end-systolic pressure-volume relationship, preload recruitable stroke work, contractility index and dP/dtmax. It also impaired diastolic function by significantly increased end-diastolic pressure-volume relationship, tau and dP/dtmin. These results suggested that acute effects of dronedarone produced negative dromotropy, inotropy and lusitropy in anesthetized dogs. Care should be taken when given dronedarone to dogs, especially when the patients have impaired cardiac function.

【 授权许可】

Unknown