Effect of Pravastatin on Echocardiographic Circulation Parameters inDogs

Journal of Veterinary Medical Science

Noboru ARITA¹  Shinji ARITA²  Yoshiaki HIKASA² 

[1] Arita Sougo Animal Hospital, 1�?14�?6 Nishi, Hachihonmatsu, Higashihiroshima, Hiroshima 739�?0147, Japan;Laboratory of Veterinary Internal Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4�?101 Koyama-Minami, Tottori 680�?8553, Japan

关键词: canine;    cardiac function;    echocardiography;    hemodynamics;    pravastatin;   

DOI  :  10.1292/jvms.13-0505

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(41)Cited-By(1)The purpose of this study was to determine the effect of pravastatin (PS) onhemodynamic parameters in healthy dogs. Five beagle dogs were repeatedly used in each ofthe 4 groups. One group was not medicated (control). Dogs in other groups received 0.5,1.0 or 2.0 mg/kg PS orally q24hr, for 4 weeks. Physical examination, blood biochemicaltests, blood pressure measurements and Doppler echocardiography were performed before and1, 2 and 4 weeks after PS administration in all dogs. PS significantly reduced the leftatrial-to-aortic diameter ratio (LA/Ao), early diastolic transmitral flow (E) wave,E/early diastolic mitral annulus motion velocity (Em) ratio, left ventricular (LV)fractional shortening, LV ejection fraction, mid systolic myocardial velocity gradient,stroke volume (SV), cardiac output (CO), right and left ventricular Tei indices andelevated Em and early diastolic myocardial velocity gradient. Heart rate was notsignificantly altered during PS administration, but mean blood pressure decreasedslightly. The hematological and blood biochemical values were within normal limits duringPS administration. These results revealed that PS administration increases LV expansioncapacity and decreases LV constriction and left atrial pressure. It has been suggestedthat PS may be effective in improving heart failures with LV diastolic dysfunction orelevated left atrial pressure in dogs.

【 授权许可】

Unknown