Endocrine Journal | |
Effect of 1α-Hydroxyvitamin D3 on Loss of Bone Mineral Density Immediately after Artificial Menopause | |
JUI-TUNG CHEN2  YASUO HIRAI2  ETSURO OGATA3  MASATAKA SHIRAKI1  KATSUYOSIHI KATASE2  KATSUHIKO HASUMI2  YUMIKO SHIRAKI1  TOMOYASU KATO2  | |
[1] Research Institute and Practice for Involutional Disease;Department of Gynecology, Cancer Institute Hospital;Department of Internal Medicine, Cancer Institute Hospital | |
关键词: 1α-Hydroxyvitamin D3; Bone mineral density; Artificial menopause; Osteoporosis; | |
DOI : 10.1507/endocrj.44.299 | |
学科分类:内分泌与代谢学 | |
来源: Japan Endocrine Society | |
【 摘 要 】
References(15)Cited-By(1)To evaluate the effects of 1α-hydroxyvitamin D3 (1α(OH)D3), a series of clinical trials, preventive and therapeutic, were performed in an open label manner in women immediately after oophorectomy. The series included a total of 121 oophorectomized subjects, whose lumbar bone mineral density (L2-4BMD) was followed by the use of dual energy X-ray absorptiometry. (1) Preventive trial: 61 women who had undergone premenopausal bilateral oophorectomy, were divided into 3 groups (Group C: control; Group L: 0.25μg 1α(OH)D3/day; Group H: 0.50-0.75μg 1α(OH)D3/day). The changes in BMD and chemical indices were followed up for one year. (2) Therapeutic trial: the trial included 60 premenopausally oophorectomized subjects having L2-4BMD lower than the normal control level minus 1SD which has been reported in age-matched normal Japanese women. These subjects were divided into 3 groups and treated in the same way as in the preventive trial. In the preventive trial, L2-4BMD decreased by 8.2%, 6.5% and 4.5% in groups C, L and H, respectively, at 12 months of treatment, whereas in the therapeutic trial, L2-4BMD decreased by 3.6%, 3.2% and 0.8% in the groups C, L and H, respectively, at 12 months of treatment. In conclusion, 1α(OH)D3 was found to be effective both to prevent the bone loss subsequent to bilateral oophorectomy and improve low bone mass after oophorectomy.
【 授权许可】
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