Glucose-Dependent Insulinotropic Polypeptide Induced Growth Hormone Secretion in Acromegaly

Endocrine Journal

Mitsuhiko UMAHARA²  Kihachi OHSHIMA¹  Masatomo MORI³  Shuichi OKADA³ 

[1] Health and Medical Center, Gunma University,;Public Nanokaichi Hospital, Department of Internal Medicine;Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine,

关键词: Acromegaly;    GIP;    GH;   

DOI  :  10.1507/endocrj.50.643

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(33)Cited-By(3)Glucose-dependent insulinotropic polypeptide (GIP), a peptide released from the intestines after meals, is thought to stimulate insulin secretion. GIP receptor cDNA has recently been cloned and its mRNA has been recognized in several organs including the pituitary, but the physiological roles of GIP receptors of the pituitary have yet to be determined. We have demonstrated the possibility that GIP stimulates GH secretions from the pituitary adenoma cells of acromegalics. GIP-stimulated GH responses were studied in four acromegalics. In two acromegalics whose GH showed paradoxical secretion to oral glucose tolerance test (OGTT), GIP infusion (0.6 μg/kg/h) drove GH secretion (13.7 to 68.1, 22.5 to 76.2 ng/ml, respectively). However, in the other two acromegalics whose GH showed no paradoxical response to OGTT, GIP infusion did not induce GH secretion. One of the patients who was studied extensively had a GH that responded to OGTT. This patient's serum GH levels increased after meals while adenomectomy abolished both the paradoxical GH secretions by OGTT and GH responses to the GIP infusion. These data suggested that some somatotroph adenoma cells have an aberrant response to GIP which may go toward explaining paradoxical GH secretions to OGTT in acromegalics.

【 授权许可】

Unknown