Histopathological Improvement of Acromegalic Cardiomyopathy by Intermittent Subcutaneous Infusion of Octreotide

Endocrine Journal

KATSUMI INOUE¹  NOBUAKI NAKAMURA¹  YOSHIO MURAKAMI²  YASUTOSHI GOTO¹  KUNIO KOSHIMURA²  MOTOI SOHMIYA²  MASATERU NISHIKI²  YUZURU KATO² 

[1] Department of Cardiology, Matsue Red Cross Hospital;First Division, Department of Medicine, Shimane Medical University

关键词: Acromegaly;    Cardiomyopathy;    GH;    Octreotide;    Myocardial biopsy;    Electron microscopy;   

DOI  :  10.1507/endocrj.44.655

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(17)Cited-By(10)We studied functional and histopathological changes in acromegalic cardiomyopathy following intermittent subcutaneous infusion of octreotide. A 68-year-old female patient with acromegaly associated with congestive heart failure due to dilated cardiomyopathy was initially treated with cardioactive medication for three months, but it was not effective in correcting echocardiographic abnormalities. Further treatment with intermittent subcutaneous infusion of octreotide (20μg/2 h) for 12 months not only reduced circulating GH and insulin-like growth factor-I (IGF-I) levels but also considerably improved histopathological changes in the myocardial specimen biopsied. These findings provide the first evidence of the favorable effect of octreotide on histopathological changes in acromegalic Cardiomyopathy.

【 授权许可】

Unknown