Prognostic classification of thyroid follicular cell tumors using Ki-67 labeling index: Risk stratification of thyroid follicular cell carcinomas [Review]

Endocrine Journal

Katsunari Yane⁴  Hiroyuki Yamashita¹  Tomoko Wakasa³  Kennichi Kakudo³  Yasuhiro Ito²  Yoshio Ohta³ 

[1] Department of Surgery, Yamashita Thyroid and Parathyroid Clinic, Fukuoka-city 812-0034, Japan;Department of Surgery, Kuma Hospital, Kobe-city 650-0011, Japan;Department of Pathology and Laboratory Medicine, Nara Hospital Kinki University Faculty of Medicine, Ikoma-city 630-0293, Japan;Department of Otolaryngology-Head and Neck Surgery, Nara Hospital Kinki University Faculty of Medicine, Ikoma-city 630-0293, Japan

关键词: Thyroid carcinoma;    Ki-67;    Proliferation index;    Risk stratification;    Prognosis;   

DOI  :  10.1507/endocrj.EJ14-0293

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(73)This review emphasizes that the so-called high-risk thyroid carcinoma is not a distinct tumor entity, but a group of tumors with different histologies.High-grade histological features, such as tumor necrosis, increased mitoses, and nuclear pleomorphism, together with high Ki-67 labeling index (more than 10%), are good indicators of high-risk thyroid carcinoma and suggest a possible risk for anaplastic transformation.This review proposes the stratification of patients with thyroid carcinoma into low-, moderate-, and high-risk groups based on Ki-67 labeling index, which should be useful for the clinical management of patients, even after initial surgery.Currently, both the aggressive variant of papillary carcinoma and poorly differentiated carcinoma are aggressively treated by a completion of total thyroidectomy with prophylactic lymph node dissection followed by radioactive iodine treatment.Therefore, patients with moderate-risk or high-risk thyroid carcinoma based on Ki-67 labeling index should also be considered candidates for this treatment strategy.

【 授权许可】

Unknown