Experimental Sensitization with Japanese Cedar Pollen in Dogs

Journal of Veterinary Medical Science

Atsuhiko HASEGAWA⁶  Kenichi MASUDA⁴  Koichi OHNO⁴  Hajime TSUJIMOTO⁴  Yuhsi MATSUO⁵  Douglas J. DEBOER²  Taihei ODAGIRI³  Kohei YAMASHITA³  Mitsuo YAMAKI³  Yoshiki NAKAO³  Masahiro SAKAGUCHI¹ 

[1] Department of Immunology,National Institute of Infectious Diseases,Tokyo 162-0052,Japan;Department of Medical Sciences,School of Veterinary Medicine,University of Wisconsin,Madison,U.S.A.;Pharmaceutical Research Laboratory,Hitachi Chemical Co.,Ltd.,4-13-1 Higashi-cho,Hitachi-shi,Ibaraki 317-8555,Japan;Department of Veterinary Internal Medicine,Graduate School of Agricultural and Life Sciences,The University of Tokyo,Tokyo 113-8657,Japan;Nagahama Institute for Biochemical Science,Oriental Yeast Co.,Ltd.,Shiga 526-0804,Japan;Department of Pathobiology,Nihon University School of Veterinary Medicine,Kanagawa 252-0813,Japan

关键词: canine;    IgE antibody;    Japanese cedar;   

DOI  :  10.1292/jvms.62.1223

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(9)Japanese cedar pollinosis is a type I allergic disease mediated by immunoglobulin E(IgE)antibodies to Japanese cedar(Cryptomeria japonica)pollen antigen(CPAg).By using 22 dogs consisting of 20 dogs aged 3 months and 2 dogs aged 3 years, immunization was performed by subcutaneous injections of CPAg with aluminum hydroxide gel.Variable levels of CPAg−specific IgE antibody response were detected in 21 of the 22 immunized dogs two weeks after the second immunization.This study provided an experimental sensitization system with CPAg in dogs, which will be useful for further immunological studies on Japanese cedar pollinosis.

【 授权许可】

Unknown