Immune Responses to Inhalant Allergens

World Allergy Organization Journal

Belinda J Hales¹  Wayne R Thomas¹ 

[1] Centre for Child Health Research, University of Western Australia, Telethon Institute for Health Research, Western Australia

关键词: immunoregulation;    IgE antibody;    IgG antibody;    T cells;    B cells;    allergens;   

Others  :  824541
DOI  :  10.1097/WOX.0b013e3181788324

 received in 2008-01-15, accepted in 2008-04-01,  发布年份 2008

【 摘 要 】

This overview describes the nature of the immune responses induced by the inhalation of allergens. There is a dichotomy in that B cells have multiple mechanisms that limit the amount of immunoglobulin E (IgE) antibody production, whereas T-cell responses are large even in nonallergic subjects. With the possible exception of responses to cat allergen, however, T cells from nonallergic subjects have limited effector function of helping IgG antibody, and in house-dust mite allergy, this declines with age. Regulation by interleukin 10 (IL-10)-producing cells and CD25⁺ T-regulatory cells has been proposed, but critically, there is limited evidence for this, and many studies show the highest IL-10 production by cells from allergic subjects. Recent studies have shown the importance of nonlymphoid chemokines thymic stromal lymphopoietin and IL-27, so studying responses in situ is critical. Most sources of allergens have 1 or 2 dominant allergens, and for house-dust mite, it has been shown that people have a predictable responsiveness to high-, mid-and poor-IgE-binding proteins regardless of the total size of their response. This allergen hierarchy can be used to design improved allergen preparations and to investigate how antiallergen responses are regulated.

【 授权许可】

   
2008 World Allergy Organization; licensee BioMed Central Ltd.

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