Endocrine Journal | |
Normal Delivery Following an Uneventful Pregnancy in a Japanese Acromegalic Patient after Discontinuation of Octreotide Long Acting Release Formulation at an Early Phase of Pregnancy | |
Takao YOSHIDA1  Takashi IIZUKA2  Hiroko ITO2  Jun SAITO2  Tatsuro TAKANO2  Tetsuo NISHIKAWA2  Akiko SOYAMA2  | |
[1] The Department of Obstetrics and Gynecology, Kyoritsu Narashinodai Hospital;Department of Medicine, Yokohama Rosai Hospital | |
关键词: Acromegaly; Pregnancy; Delivery; Octreotide LAR; | |
DOI : 10.1507/endocrj.53.209 | |
学科分类:内分泌与代谢学 | |
来源: Japan Endocrine Society | |
【 摘 要 】
References(21)Cited-By(11)We report a 35-year-old woman with active acromegaly despite pituitary surgery and irradiation who received continuous octreotide LAR treatment for the control of GH excess until discovery of her pregnancy. The patient delivered a healthy boy following an uneventful pregnancy after discontinuing octreotide LAR as soon as possible at the early phase of pregnancy. Despite a substantial maternal-fetal transfer of octreotide, postnatal development was normal at 3 years of age. In almost all previously described cases, octreotide was discontinued after pregnancy was confirmed. No side-effects of mother or fetus have been reported. Octreotide treatment in pregnancy seems to be feasible and safe. Due to the still-limited number of reported cases treated with octreotide LAR, the potential benefits of octreotide LAR treatment should be weighed carefully against its possible risks.
【 授权许可】
Unknown
【 预 览 】
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RO201911300051377ZK.pdf | 115KB | download |