Suppressed levels of growth hormone and insulin-like growth factor-1 during successful pregnancy in persistent acromegaly

Endocrine Journal

Tetsuya Tagami²  Hideshi Kuzuya²  Jun A. Takahashi¹  Akira Shimatsu²  Takeshi Usui² 

[1] Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan;Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan

关键词: Acromegaly;    Pregnancy;    IGF-1;    Octreotide;    Radiosurgery;   

DOI  :  10.1507/endocrj.K10E-069

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(17)Cited-By(3)Pregnancy is a rather rare event in acromegaly because fertility is often reduced during active disease. Previous reports of pregnancy in acromegalic patients showed that the pituitary growth hormone (GH) level was unaffected and the insulin-like growth factor (IGF)-1 level was elevated during the second and third trimesters. We describe here a case of persistent acromegaly that showed suppressed levels of GH and IGF-1 during pregnancy. The suppression of GH secretion and IGF-1 may be due to increased estrogen or other factors circulating in mid- to late pregnancy.

【 授权许可】

Unknown