Long-Term Effects of Dietary Fiber Supplementation on Serum Glucose and Lipoprotein Levels in Diabetic Rats Fed a High Cholesterol Diet

Endocrine Journal

KUNIHIRO DOI³  MUNEYOSHI YOSHIDA²  JYUNKO SAWA²  TSUTOMU KAZUMI¹  YOSHIHIKO ISHIDA¹  TOSHIKI HOZUMI¹  HIDEKI MIMOTO³ 

[1] Division of Endocrinology and Metabolism, Department of Medicine, Hyogo Medical Center for Adults;Himeji College of Hyogo;Metabolic Unit, Kobe University School of Medicine

关键词: Glucomannan;    Streptozotocin diabetes;    Cholesterol feeding;    Lipoproteins;   

DOI  :  10.1507/endocrj.42.187

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(29)Cited-By(17)We have shown that cholesterol-fed diabetic rats developed atheromatous lesions in the aorta and coronary arteries, which were not observed in cholesterol-fed diabetic rats receiving concomitant supplementation with 15% glucomannan, a soluble dietary fiber concentrate. The present study was designed to examine the effects of the dietary fiber supplementation on serum levels of glucose and lipoproteins in cholesterol-fed diabetic rats. Feeding a diet containing 1.5% cholesterol (wt/wt) and 0.37% cholic acid for 18 weeks to rats made diabetic by streptozotosin (35mg/kg body weight, iv) produced moderate hyperglycemia and moderate hypercholesterolemia, the latter being characterized by high concentrations not only of low density lipoproteins but also intermediate density lipoproteins and very low density lipoproteins. These changes in serum lipoproteins and hyperglycemia were substantially reduced by 18 weeks of supplementation with glucomannan but high density lipoprotein cholesterol and triglyceride levels did not change after feeding a cholesterol-rich diet in the presence or absence of glucomannan supplementation. These results suggest that amelioration in hyperlipoproteinemia and hyperglycemia induced by the dietary fiber supplementation may help retard or prevent the atheromatous formation found in cholesterol-fed diabetic rats.

【 授权许可】

Unknown