Comparison of effects of insulin aspart three times a day versus insulin detemir once a day on oxidative stress in patients with type 2 diabetes

Endocrine Journal

Kimio Morita¹  Rika Naruse¹  Kohzo Takebayashi¹  Yoshimasa Aso¹  Toshihiko Inukai¹ 

[1] Department of Internal Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan

关键词: Insulin;    Oxidative stress;    Type 2 diabetes;   

DOI  :  10.1507/endocrj.K11E-114

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(30)Cited-By(2)The main purpose of this study was to investigate whether treatment with long-acting insulin once a day or short-acting insulin three times before each meal daily has a stronger antioxidative effect in patients with type 2 diabetes.These patients had not been treated previously with insulin and were hospitalized for initiation of glycemic control by insulin injection.The patients (n =43) were assigned consecutively and alternately to a group treated with insulin aspart injection three times daily just before each meal and a group treated with insulin detemir injection once daily before bedtime.The results showed that insulin aspart three times a day produced a greater improvement in plasma glucose, and particularly in mean postprandial plasma glucose, compared with insulin detemir once a day (p =0.0006 for comparison of changes between the two insulin treatments).The amount of insulin needed to approach the target levels of plasma glucose was larger in the insulin aspart group (26.0 ± 10.7 U/day vs. 13.7 ± 4.9 U/day; p p =0.0079), although the mechanisms are not fully evident.

【 授权许可】

Unknown