Antioxidant α‐tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes

FEBS Letters

Ban, Nobuhiro¹  Miyawaki, Kazumasa¹  Seino, Yutaka¹  Hiai, Hiroshi²  Kuroe, Akira¹  Yamada, Yuichiro¹  Kubota, Akira¹  Adachi, Tetsuya¹  Iwakura, Toshio¹  Toyokuni, Shinya²  Ihara, Yu¹ 

[1] Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan;Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan

关键词: Oxidative stress;    Type 2 diabetes;    α-Tocopherol;    Glucose metabolism;    Insulin;   

DOI  :  10.1016/S0014-5793(00)01489-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have shown recently that oxidative stress by chronic hyperglycemia damages the pancreatic β-cells of GK rats, a model of non-obese type 2 diabetes, which may worsen diabetic condition and suggested the administration of antioxidants as a supportive therapy. To determine if natural antioxidant α-tocopherol (vitamin E) has beneficial effects on the glycemic control of type 2 diabetes, GK rats were fed a diet containing 0, 20 or 500 mg/kg diet α-tocopherol. Intraperitoneal glucose tolerance test revealed a significant increment of insulin secretion at 30 min and a significant decrement of blood glucose levels at 30 and 120 min after glucose loading in the GK rats fed with high α-tocopherol diet. The levels of glycated hemoglobin A1c, an indicator of glycemic control, were also reduced. Vitamin E supplementation clearly ameliorated diabetic control of GK rats, suggesting the importance of not only dietary supplementation of natural antioxidants but also other antioxidative intervention as a supportive therapy of type 2 diabetic patients.

【 授权许可】

Unknown