Epidemiological Characterization of Newly Recognized Rat Parvovirus, "Rat Orphan Parvovirus"

Journal of Veterinary Medical Science

Yutaka UENO¹  Ken-ichi YAGAMI¹  Kazutaka OHSAWA²  Fumihiro SUGIYAMA¹  Hiroshi SATO²  Yoshihiro SUGIYAMA¹ 

[1] Laboratory Animal Research Center, University of Tsukuba;Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine

关键词: orphan parvovirus;    PCR;    rat;    viral excretion;    viral persistence;   

DOI  :  10.1292/jvms.59.265

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(4)Newly recognized rat parvovirus (rat orphan parvovirus: ROPV) was examined for viral excretion and persistence in infected rats, and also for infectivity to mice and hamsters. The virus appeared to replicate mainly in lymphoid or hematopoietic tissues, and was detected in feces, urine and oropharynx of the infected rats at 1 to 4 weeks postinfection. The infective virus was also detected in peripheral leukocytes and various tissues at an acute phase of infection, and decreased in every tissue at 8 weeks postinfection. Viral DNA, however, was persistent in lymphoid tissues at least up to 24 weeks postinfection. When the virus was inoculated to mice and hamsters, no evidence of viral production and antibody response was demonstrated. ROPV is assumed to be a variant of the known rat parvovirus which resulted to alter cell tropism and persist in lymphoid or hematopoietic tissues, in order to escape from host immune system.

【 授权许可】

Unknown