Improvement of health-related quality of life in adult women with 21-hydroxylase deficiency over a seven-year period

Endocrine Journal

Benjamin Bleicken¹  Manfred Ventz¹  Andreas Hinz²  Marcus Quinkler¹ 

[1] Department of Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Germany;Department of Medical Psychology and Sociology, University of Leipzig, Leipzig, Germany

关键词: Congenital adrenal hyperplasia;    Hydrocortisone;    Prednisolone;    Dexamethasone;    Short Form 12 (SF-12);   

DOI  :  10.1507/endocrj.EJ12-0183

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(31)Cited-By(3)Health related quality of life (HRQoL) is impaired in adult patients with 21-hydroxylase deficiency (21-OHD).Up to now, only cross-sectional and no longitudinal studies are available.It is not known if HRQoL can be improved in adult 21-OHD patients.We performed a longitudinal, prospective, single centre, follow-up study over seven years including 15 adult female 21-OHD patients.Two standardized questionnaires (Short Form 12 (SF-12); Hospital Anxiety and Depression Scale (HADS)) were completed in 2003, 2006 and 2010.Adjustment for age and sex was performed by transformation of score values into age- and sex-adjusted Z-scores using data sets from respective normative groups.Data regarding glucocorticoid therapy, clinical and hormonal parameters were assessed.We found that two of eight scales of SF-12 showed a significant improvement and four of eight scales a positive trend to better scores.No significant changes were seen in scores for HADS or for steroid hormone levels.Daily hydrocortisone equivalent dose per body surface significantly decreased over the study period.No changes in BMI were observed over the study period.We conclude that improvement of HRQoL in adult female 21-OHD patients is possible.Several factors might be involved in this improvement including reduced daily hydrocortisone equivalent dose per body surface.

【 授权许可】

Unknown