Tumor size is the strongest predictor of microscopic lymph node metastasis and lymph node recurrence of N0 papillary thyroid carcinoma

Endocrine Journal

Yuuki Takamura¹  Akihiro Miya¹  Minoru Kihara¹  Yasuhiro Ito¹  Kaoru Kobayashi¹  Mitsuhiro Fukushima¹  Takuya Higashiyama¹  Akira Miyauchi¹ 

[1] Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan

关键词: Papillary thyroid carcinoma;    Microscopic lymph node metastasis;    Tumor size;   

DOI  :  10.1507/endocrj.EJ12-0311

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(19)Cited-By(10)It is well-known that papillary thyroid carcinoma (PTC) frequently metastasizes to the regional (central and lateral) lymph nodes, even though it is diagnosed as node-negative on preoperative imaging studies.In this study, we investigated predictors of microscopic node metastasis and lymph node recurrence of PTC without node metastasis detected preoperatively (N0).Of the clinicopathological features that can be evaluated pre- and intraoperatively, tumor size (> 2 cm) was the strongest predictor of microscopic central and lateral node metastasis on multivariate logistic analysis.Also, the tumor size most markedly affected lymph node recurrence, but not distant recurrence.Lymph node recurrence may not be immediately life-threatening, but it can be a stressor both for physicians and patients.Therefore, careful lymph node dissection is recommended for PTC with a large size, even though it is prophylactic.

【 授权许可】

Unknown