Radiopharmaceutical development based on human blood albumin microspheres and 90Y

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Petriev, V.M.^1,2 ; Vlasova, O.P.^2 ; Postnov, A.A.^2 ; Epstein, N.B.^2

Tsyb Medical Radiological Research Centre - Branch, National Medical Research Radiological Centre, Ministry of Health of the Russian Federation (A. Tsyb MRCC), Obninsk, Kaluga region, Russia^1

National Research Nuclear University, MEPhI, Moscow, Russia^2

关键词: High specific activities;    Human bloods;    Human serum albumins;    Liver cancers;    Optimized synthesis;    Tumor site;    Tumor size;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012046/pdf
DOI  :  10.1088/1742-6596/784/1/012046

来源: IOP

【 摘 要 】

New radiopharmaceutial (RP) based on human serum albumin microspheres (MSA) and90Y was developed for treatment of liver cancer. The optimized synthesis using chelation resulted in approximately 80% yield with high specific activity. The RP developed was tested in mice with inoculated sarcoma-37. In two weeks the tumor size reduced by 43% after the treatment with the dose of 500 μCi injected into the tumor site.