Effect of Immunostimulation by Detoxified E. coli Lipopolysaccharide Combined with Inactivated Propionibacterium granulosum Cells on Porcine Immunity

Journal of Veterinary Medical Science

Chien-Ning HUNG²  Shih-Ling HSUAN²  Ter-Hsin CHEN²  Dan-Yuan LO²  Jiunn-Wang LIAO²  Maw-Sheng CHIEN²  Barbara A BLACKLAWS¹  Wei-Cheng LEE² 

[1] Centre of Veterinary Science, Department of Veterinary Medicine, Cambridge University;Graduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University

关键词: adjuvant effect;    immunomodulation;    leukocyte function;    lipopolysaccharide;    Propionibacterium granulosum;   

DOI  :  10.1292/jvms.71.897

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(37)Cited-By(1)The aim of this experiment was to evaluate the immunomodulating activities of inactivated Propionibacterium granulosum cell walls and E. coli lipopolysaccharide (PG/LPS) on porcine immunity. Piglets were intramuscularly administered PG/LPS (1 ml/10 kg body weight) once or twice. The function of natural killer cells, lymphocytes and neutrophils and the adjuvant effect on antibody induction by attenuated classical swine fever virus (CSFV) and inactivated Mycoplasma hyopneumoniae vaccination were evaluated. The results showed that the cytotoxicity of natural killer cells and proliferation of lymphocytes in response to mitogen stimulation were significantly enhanced (P<0.05) in those pigs receiving PG/LPS injection compared with the controls. However, there was no significant effect on the phagocytic activity of neutrophils (P>0.05). PG/LPS also displayed adjuvant effects with CSFV and Mycoplasma hyopneumoniae vaccines. Moreover, pigs receiving two injections of PG/LPS showed a 20.8% growth enhancement compared with untreated pigs. Thus, PG/LPS caused positive immunoregulation of porcine innate immune system effectors, non-specific activation of lymphocytes and antibody production.

【 授权许可】

Unknown