Membranoproliferative Glomerulonephritis in a Young Cat

Journal of Veterinary Medical Science

Koichi OHNO³  Kikumi OGIHARA⁴  Junichi KAMIIE²  Kinji SHIROTA¹  Atsushi TSUKAMOTO³  Tomoko ASANO¹ 

[1] Research Institute of Biosciences, Azabu University;Laboratory of Veterinary Pathology, Azabu University;Department of Veterinary Internal Medicine, The University of Tokyo;Laboratory of Environmental Pathology, Azabu University

关键词: feline;    glomerulus;    pathology;   

DOI  :  10.1292/jvms.70.1373

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(9)Cited-By(1)A 9-month-old male Japanese domestic cat showed pleural effusion, ascites, azotemia, hypoproteinemia and severe proteinuria. Histopathology of the percutaneous renal biopsy specimen revealed that all glomeruli showed intense mesangial hypercellularity with an increased mesangial matrix and thickening of the capillary walls, resulting in lobular accentuation of the glomerular tufts. Frequent duplication of the capillary walls was also observed. Immunostaining for α-smooth muscle actin distinctly revealed mesangial interposition. Diffuse global and linear deposition of C3 and IgG was observed mostly along the peripheral capillary loops. Electron microscopy confirmed frequent circumferential mesangial interposition and subendothelial dense-deposits in the glomerulus. The glomerular lesion was consistent with human membranoproliferative glomerulonephritis type I, and might be a rare case that developed at young age.

【 授权许可】

Unknown