Sympathetic Activation of Hepatic and Splenic IL-1β mRNA Expression during Oscillation Stress in the Rat

Journal of Veterinary Medical Science

Bae Dong JUNG¹  Kazuhiro KIMURA¹  Kennedy MAKONDO¹  Hiroshi KITAMURA¹  Masayuki SAITO¹  Katsushi KANEHIRA¹ 

[1] Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan

关键词: Interleukin-1;    Kupffer cell;    macrophage;    oscillation stress;    sympathetic nerve;   

DOI  :  10.1292/jvms.62.409

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(6)Interleukin (IL)-1β mRNA expression in the liver and spleen was examined after subjection to oscillation stress in the rat. Thirty-minute subjection to oscillation stress increased IL-1β mRNA expression in the both organs. Prior treatment of rats with gadolinium chloride, which eliminates macrophages, prevented the stress-induced IL-1β expression. Either adrenalectomy or treatment of guanethidine, a blocker of norepinephrine release in the sympathetic nerve endings, partially attenuated the stress-induced response, but the combined treatment completely blocked it. Injection of β-adrenergic antagonist (propranolol) also suppressed the stress-induced response. These results suggest that oscillation stress induces IL-1β mRNA expression in the liver and spleen, probably in Kupffer cells and splenic macrophages, and that stress-induced IL-1β expression is elicited by catecholamines released from sympathetic nerve terminals and the adrenal gland.

【 授权许可】

Unknown