Functional and anatomical specificity in a higher olfactory centre

eLife

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[1] Department of Zoology, University of Cambridge, Cambridge, United Kingdom;Janelia Research Campus, Howard Hughes Medical Institute, Chevy Chase, United States;Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom;Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom;Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom;Neurophysiology of Behaviour Laboratory, The Francis Crick Institute, London, United Kingdom;Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom;Department of Zoology, University of Cambridge, Cambridge, United Kingdom;Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom;Janelia Research Campus, Howard Hughes Medical Institute, Chevy Chase, United States;

关键词: olfaction;    neuroscience;    cell type;    Drosophila;    lateral Horn;    neuroanatomy;    D. melanogaster;   

DOI  :  10.7554/eLife.44590

来源: publisher

【 摘 要 】

10.7554/eLife.44590.001Most sensory systems are organized into parallel neuronal pathways that process distinct aspects of incoming stimuli. In the insect olfactory system, second order projection neurons target both the mushroom body, required for learning, and the lateral horn (LH), proposed to mediate innate olfactory behavior. Mushroom body neurons form a sparse olfactory population code, which is not stereotyped across animals. In contrast, odor coding in the LH remains poorly understood. We combine genetic driver lines, anatomical and functional criteria to show that the Drosophila LH has ~1400 neurons and >165 cell types. Genetically labeled LHNs have stereotyped odor responses across animals and on average respond to three times more odors than single projection neurons. LHNs are better odor categorizers than projection neurons, likely due to stereotyped pooling of related inputs. Our results reveal some of the principles by which a higher processing area can extract innate behavioral significance from sensory stimuli.

【 授权许可】

CC BY