Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria

eLife

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[1] Central European Institute of Technology, Brno, Czech Republic;Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso;Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso;Université Polytechnique de Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso;Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden;Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden;Unit of Infectious Diseases, Department of Medicine, Karolinska Institute, Stockholm, Sweden;

关键词: malaria;    innate immunity;    Fulani;    monocyte;    inflammasome;    transcriptome;    Human;    P. falciparum;   

DOI  :  10.7554/eLife.29156

来源: publisher

【 摘 要 】

10.7554/eLife.29156.001The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite densities compared to sympatric ethnic groups. However, the basis for this lower susceptibility to malaria by the Fulani is unknown. The incidence of classic malaria resistance genes are lower in the Fulani than in other sympatric ethnic populations, and targeted SNP analyses of other candidate genes involved in the immune response to malaria have not been able to account for the observed difference in the Fulani susceptibility to P.falciparum. Therefore, we have performed a pilot study to examine global transcription and DNA methylation patterns in specific immune cell populations in the Fulani to elucidate the mechanisms that confer the lower susceptibility to P.falciparum malaria. When we compared uninfected and infected Fulani individuals, in contrast to uninfected and infected individuals from the sympatric ethnic group Mossi, we observed a key difference: a strong transcriptional response was only detected in the monocyte fraction of the Fulani, where over 1000 genes were significantly differentially expressed upon P.falciparum infection.

【 授权许可】

CC BY