Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide‐induced inflammatory bone resorption, and protects against alveolar bone loss in mice

FEBS Open Bio

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关键词: Epigallocatechin gallate;    Lipopolysaccharide;    Bone resorption;    Periodontitis;    Prostaglandin E;    Osteoblasts;   

DOI  :  10.1016/j.fob.2015.06.003

来源: publisher

【 摘 要 】

Epigallocatechin gallate (EGCG), a major polyphenol in green tea, possesses antioxidant properties and regulates various cell functions. Here, we examined the function of EGCG in inflammatory bone resorption. In calvarial organ cultures, lipopolysaccharide (LPS)‐induced bone resorption was clearly suppressed by EGCG. In osteoblasts, EGCG suppressed the LPS‐induced expression of COX‐2 and mPGES‐1 mRNAs, as well as prostaglandin E2 production, and also suppressed RANKL expression, which is essential for osteoclast differentiation. LPS‐induced bone resorption of mandibular alveolar bones was attenuated by EGCGin vitro, and the loss of mouse alveolar bone mass was inhibited by the catechinin vivo.

【 授权许可】

Unknown