Low-dose doxycycline prevents inflammatory bone resorption in rats

Brazilian Journal of Medical and Biological Research

M.m. Bezerra²  G.a.c. Brito¹  R.a. Ribeiro²  F.a.c. Rocha¹ 

[1] ,Universidade Federal do Ceará Faculdade de Medicina Departamento de Fisiologia e Farmacologia

关键词: Tetracyclines;    Doxycycline;    Metalloproteinases;    Periodontitis;    Osteoporosis;    Bone resorption;    Inflammation;   

DOI  :  10.1590/S0100-879X2002000500015

来源: SciELO

【 摘 要 】

Matrix metalloproteinases (MMP) are considered to be key initiators of collagen degradation, thus contributing to bone resorption in inflammatory diseases. We determined whether subantimicrobial doses of doxycycline (DX) (<=10 mg kg-1 day-1), a known MMP inhibitor, could inhibit bone resorption in an experimental periodontitis model. Thirty male Wistar rats (180-200 g) were subjected to placement of a nylon thread ligature around the maxillary molars and sacrificed after 7 days. Alveolar bone loss (ABL) was measured macroscopically in one hemiarcade and the contralateral hemiarcade was processed for histopathologic analysis. Groups of six animals each were treated with DX (2.5, 5 or 10 mg kg-1 day-1, sc, 7 days) and compared to nontreated (NT) rats. NT rats displayed significant ABL, severe mononuclear cell influx and increase in osteoclast numbers, which were significantly reduced by 5 or 10 mg kg-1 day-1 DX. These data show that DX inhibits inflammatory bone resorption in a manner that is independent of its antimicrobial properties.

【 授权许可】

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